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NDB ID: NA1253    PDB ID: 3SZX 


Title:

CRYSTAL STRUCTURE OF THE TRIPLET REPEAT IN MYOTONIC DYSTROPHY REVEALS HETEROGENEOUS 1X1 NUCLEOTIDE UU INTERNAL LOOP CONFORMATIONS

Molecular Description:

5'-R(P*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3'

Structural Keywords:

DOUBLE HELIX, OVER HANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kumar, A., Park, H., Fang, P., Parkesh, R., Guo, M., Nettles, K.W., Disney, M.D.
Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations 
Biochemistry, 50, pp. 9928 - 9935, 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 39.505   b = 39.505   c = 155.887 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.7_650) program. The R value is 0.2274 for 4175 reflections in the resolution range 33.41 to 2.204 Ångstroms with Fobs >  0.13 sigma(Fobs) and with I >  0.0 sigma(I)