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NDB ID: NA1257    PDB ID: 3T5H 


Title:

TERNARY COMPLEX OF HNE ADDUCT MODIFIED DNA (5'-CXG-3' VS 13-MER) WITH DPO4 AND INCOMING DDGT

Molecular Description:

DNA polymerase IV (E.C.2.7.7.7)

Deposited:

2011-07-27

Released:

2012-02-15

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Banerjee, S., Christov, P.P., Kozekova, A., Rizzo, C.J., Egli, M., Stone, M.P.
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. 
Chem.Res.Toxicol., 25, pp. 422 - 435, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 94.815   b = 102.861   c = 53.148 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.217 for 21987 reflections in the resolution range 26.27 to 2.35 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)