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NDB ID: NA1271    PDB ID: 3TD1 


Title:

CRYSTAL STRUCTURE OF THE BACTERIAL A1408G-MUTANT AND THE PROTOZOA CYTOPLASMIC RIBOSOMAL DECODING SITE IN COMPLEX WITH GENETICIN

Molecular Description:

5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'
GENETICIN

Structural Keywords:

A DOUBLE HELIX, FLIPPED-OUT BASES, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kondo, J.
A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides 
Angew.Chem.Int.Ed.Engl., 51, pp. 465 - 468, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 33.47   b = 88.3   c = 46.21 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 8457 reflections in the resolution range 31.9 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)