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NDB ID: NA1290    PDB ID: 3THX     NAKB: NA1290 


Title:

HUMAN MUTSBETA COMPLEXED WITH AN IDL OF 3 BASES (LOOP3) AND ADP

Molecular Description:

DNA mismatch repair protein Msh2
DNA mismatch repair protein Msh3/DNA complex

Deposited:

2011-08-19

Released:

2011-12-21

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES, BULGES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Gupta, S., Gellert, M., Yang, W.
Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops 
Nat.Struct.Mol.Biol., 19, pp. 72 - 78, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 67.12   b = 91.54   c = 95.58 (Ångstroms)

α = 67.88   β = 86.51   γ = 72.86 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.212 for 49511 reflections in the resolution range 27.0 to 2.7 Ångstroms with Fobs >  1.0 sigma(Fobs) and with I >  0.0 sigma(I)