Title:
HUMAN MUTSBETA COMPLEXED WITH AN IDL OF 3 BASES (LOOP3) AND ADP
Molecular Description:
DNA mismatch repair protein Msh2
DNA mismatch repair protein Msh3/DNA complex
Deposited:
2011-08-19
Released:
2011-12-21
Structural Keywords:
B DOUBLE HELIX, OVERHANGING BASES, BULGES
Nucleic Acid Sequence:
Click to show/hide 2 nucleic acid sequences
Chain D
(DC)(DC)(DT)(DC)(DT)(DA)(DT)(DC)(DT)(DG)(DA)(DA)(DG)(DC)(DC)(DG)(DA)(DT)(DC)(DG) (DA)(DT)(
DG)(DG)
Chain E
(DT)(DC)(DA)(DT)(DC)(DG)(DA)(DT)(DC)(DG)(DA)(DC)(DA)(DG)(DC)(DT)(DT)(DC)(DA)(DG) (DA)(DT)(
DA)(DG)(DG)
Protein Sequence:
Click to show/hide 2 protein sequences
Chain A
MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVL SKMNFESFV
KDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDGQRQ VGVGYVDSIQRKLGLCEF
PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIYQD LNRLLKGKKGEQMNSAVLPEMENQVAV
SSLSAVIKFLELLSDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDT TGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRI
EERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAAN LQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRS
DFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSE LREIMNDLEKKMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLR
NNKNFSTVDIQKNGVKFTNSKLTSLN EEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPA
ILEKGQGRIILKASRHA CVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARV
GAGDSQLK GVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNNL
HVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQG EKIIQEFLS
KVKQMPFTEMSEENITIKLKQLKAEVIAKNNSFVNEIISRIKVTT
Chain B
GPKSANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRR LVAKGYKVG
VVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKE NVRDKKKGNIFIGIVGVQ
PATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVE RMDNIYFEYSHAFQAVTEFYAKDTVDI
KGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMT INGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFG
RRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLR KLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNS
HIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKV GDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQ
EFMIEIKNSAVSCIPTDWVKVGSTKA VSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAK
VAKQGDYCRPTVQEERK IVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEAT
IGIVDGIF TRMGAADNIYKGRSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCE
LEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGL INTKRKRLK
YFAKLWTMHNAQDLQKWTEEFNMEETQTS
Primary Citation:
Gupta, S., Gellert, M., Yang, W.
Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops 
Nat.Struct.Mol.Biol., 19, pp. 72 - 78, 2012.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
P 1
Cell Constants:
a = 67.12 b = 91.54 c = 95.58 (Ångstroms)
α = 67.88 β = 86.51 γ = 72.86 (degrees)
Refinement:
The structure was refined using the PHENIX program.
The R value is 0.212 for 49511 reflections in
the resolution range 27.0 to 2.7 Ångstroms
with Fobs > 1.0 sigma(Fobs) and with I > 0.0 sigma(I)