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NDB ID: NA1410    PDB ID: 4A3D 


Title:

RNA POLYMERASE II INITIAL TRANSCRIBING COMPLEX WITH A 6NT DNA-RNA HYBRID

Molecular Description:

DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (E.C.2.7.7.6)
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (E.C.2.7.7.6)
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 1
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 2
RPB7
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 3
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 5
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 4

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 12 protein sequences

Primary Citation:

Cheung, A.C.M., Sainsbury, S., Cramer, P.
Structural Basis of Initial RNA Polymerase II Transcription. 
Embo J., 30, pp. 4755 - , 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 221.91   b = 391.36   c = 283.92 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the BUSTER 2.11.2 program. The R value is 0.1616 for 168580 reflections in the resolution range 49.96 to 3.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)