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NDB ID: NA1479    PDB ID: 3V6D 


Title:

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) CROSS-LINKED WITH AZT-TERMINATED DNA

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT (E.C.2.7.7.49
2.7.7.7)
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT (E.C.2.7.7.49
2.7.7.7)

Deposited:

2011-12-19

Released:

2012-01-18

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.E., Bauman, J.D., Arnold, E.
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. 
Nat.Struct.Mol.Biol., 19, pp. 253 - 259, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.476   b = 133.171   c = 139.904 (Ångstroms)

α = 90.0   β = 98.674   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2341 for 86138 reflections in the resolution range 44.3 to 2.7048 Ångstroms with Fobs >  1.39 sigma(Fobs) and with I >  0.0 sigma(I)