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NDB ID: NA1485    PDB ID: 3UZS 


Title:

STRUCTURE OF THE C13.28 RNA APTAMER BOUND TO THE G PROTEIN-COUPLED RECEPTOR KINASE 2-HETEROTRIMERIC G PROTEIN BETA 1 AND GAMMA 2 SUBUNIT COMPLEX

Molecular Description:

Beta-adrenergic receptor kinase 1 (E.C.2.7.11.15)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Tesmer, V.M., Lennarz, S., Mayer, G., Tesmer, J.J.
Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. 
Structure, 20, pp. 1300 - 1309, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 3 1 2

Cell Constants:

a = 257.277   b = 257.277   c = 99.429 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.6.0117 program. The R value is 0.18758 for 11919 reflections in the resolution range 19.99 to 4.52 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)