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NDB ID: NA1547    PDB ID: 3V79 


Title:

STRUCTURE OF HUMAN NOTCH1 TRANSCRIPTION COMPLEX INCLUDING CSL, RAM, ANK, AND MAML-1 ON HES-1 PROMOTER DNA SEQUENCE

Molecular Description:

Transcription activation/repressor/DNA complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Choi, S.H., Wales, T.E., Nam, Y., O'Donovan, D.J., Sliz, P., Engen, J.R., Blacklow, S.C.
Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes. 
Structure, 20, pp. 340 - 349, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 63 2 2

Cell Constants:

a = 272.646   b = 272.646   c = 119.987 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.2128 for 40195 reflections in the resolution range 50.0 to 3.85 Ångstroms with Fobs >  1.0 sigma(Fobs) and with I >  0.0 sigma(I)