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NDB ID: NA1574    PDB ID: 4DL3 


Title:

HUMAN DNA POLYMERASE ETA INSERTING DCMPNPP OPPOSITE GG TEMPLATE (GG0B).

Molecular Description:

DNA polymerase eta (E.C.2.7.7.7)/DNA

Deposited:

2012-02-05

Released:

2012-05-09

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhao, Y., Biertumpfel, C., Gregory, M.T., Hua, Y.J., Hanaoka, F., Yang, W.
Structural Basis for Chemoresistance to Cisplatin Mediated by DNA Polymerase eta 
Proc.Natl.Acad.Sci.USA, 109, pp. 7269 - 7274, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 97.38   b = 97.38   c = 81.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.205 for 25208 reflections in the resolution range 30.0 to 2.1 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)