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NDB ID: NA1594    PDB ID: 4DQY 


Title:

STRUCTURE OF HUMAN PARP-1 BOUND TO A DNA DOUBLE STRAND BREAK

Molecular Description:

Poly [ADP-ribose] polymerase 1

Deposited:

2012-02-16

Released:

2012-05-30

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Langelier, M.F., Planck, J.L., Roy, S., Pascal, J.M.
Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. 
Science, 336, pp. 728 - 732, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 65.095   b = 112.965   c = 294.724 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.24156 for 31628 reflections in the resolution range 20.0 to 3.25 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)