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NDB ID: NA1658    PDB ID: 4A93 


Title:

RNA POLYMERASE II ELONGATION COMPLEX CONTAINING A CPD LESION

Molecular Description:

DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (E.C.2.7.7.6)
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (E.C.2.7.7.6)
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 1
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 2
RPB7
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 3
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 5
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11
DNA-DIRECTED RNA POLYMERASES I
II
AND III SUBUNIT RPABC 4

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 12 protein sequences

Primary Citation:

Walmacq, C., Cheung, A.C., Kireeva, M.L., Lubkowska, L., Ye, C., Gotte, D., Strathern, J.N., Carell, T., Cramer, P., Kashlev, M.
Mechanism of Translesion Transcription by RNA Polymerase II and its Role in Cellular Resistance to DNA Damage. 
Mol.Cell, 46, pp. 18 - , 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 221.637   b = 391.519   c = 281.774 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (PHENIX.REFINE) program. The R value is 0.1656 for 167169 reflections in the resolution range 54.093 to 3.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)