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NDB ID: NA1662    PDB ID: 4E78 


Title:

CRYSTAL STRUCTURE OF A PRODUCT STATE ASSEMBLY OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH BETA HAIRPIN LOOP DELETION BOUND TO PRIMER-TEMPLATE RNA WITH 3'-DG

Molecular Description:

PROTEIN/RNA Complex

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Mosley, R.T., Edwards, T.E., Murakami, E., Lam, A.M., Grice, R.L., Du, J., Sofia, M.J., Furman, P.A., Otto, M.J.
Structure of hepatitis C virus polymerase in complex with primer-template RNA. 
J.Virol., 86, pp. 6503 - 6511, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65

Cell Constants:

a = 143.27   b = 143.27   c = 92.19 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.6.0117 program. The R value is 0.2 for 23671 reflections in the resolution range 50.0 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)