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NDB ID: NA1687    PDB ID: 4E9F 


Title:

STRUCTURE OF THE GLYCOSYLASE DOMAIN OF MBD4 BOUND TO AP SITE CONTAINING DNA

Molecular Description:

Methyl-CpG-binding domain protein 4 (E.C.3.2.2.-)/DNA complex

Deposited:

2012-03-21

Released:

2012-08-08

Structural Keywords:

B DOUBLE HELIX, BULGES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Morera, S., Grin, I., Vigouroux, A., Couve, S., Henriot, V., Saparbaev, M., Ishchenko, A.A.
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA. 
Nucleic Acids Res., 40, pp. 9917 - 9926, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 41.07   b = 55.84   c = 96.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the BUSTER program. The R value is 0.2158 for 21487 reflections in the resolution range 37.8 to 1.79 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)