A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 22-Jun-2022 number of released structures: 12128
Search for released structures

NDB ID: NA1699    PDB ID: 4EBE 


Title:

CONFORMATIONALLY RESTRAINED NORTH-METHANOCARBA-2'-DEOXYADENOSINE CORRECTS THE ERROR-PRONE NATURE OF HUMAN DNA POLYMERASE IOTA

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA complex

Deposited:

2012-03-23

Released:

2012-06-13

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ketkar, A., Zafar, M.K., Banerjee, S., Marquez, V.E., Egli, M., Eoff, R.L.
A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota. 
J.Am.Chem.Soc., 134, pp. 10698 - 10705, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.233   b = 98.233   c = 202.067 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2222 for 32614 reflections in the resolution range 44.173 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  1.0 sigma(I)