NDB ID: NA1892    PDB ID: 4FS1     NAKB(beta): NA1892 

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Title:

BASE PAIRING MECHANISM OF N2,3-ETHENOGUANINE WITH DTTP BY HUMAN POLYMERASE IOTA

Molecular Description:

DNA polymerase iota/DNA Complex
THYMIDINE-5'-TRIPHOSPHATE

Deposited:

2012-06-26

Released:

2012-08-29

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhao, L., Pence, M.G., Christov, P.P., Wawrzak, Z., Choi, J.Y., Rizzo, C.J., Egli, M., Guengerich, F.P.
Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases. 
J.Biol.Chem., 287, pp. 35516 - 35526, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 97.47   b = 97.47   c = 203.541 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.218 for 19448 reflections in the resolution range 84.41 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)

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Biological Assembly coordinates (pdb format) 1

Structure Factors (cif format)

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Coordinates (cif format, Unix compressed(.gz))

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