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NDB ID: NA1914    PDB ID: 4FM9 


Title:

HUMAN TOPOISOMERASE II ALPHA BOUND TO DNA

Molecular Description:

DNA topoisomerase 2-alpha (E.C.5.99.1.3)/DNA complex

Deposited:

2012-06-15

Released:

2012-08-08

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wendorff, T.J., Schmidt, B.H., Heslop, P., Austin, C.A., Berger, J.M.
The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage. 
J.Mol.Biol., 424, pp. 109 - 124, 2012.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 85.918   b = 215.081   c = 128.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2291 for 25373 reflections in the resolution range 49.611 to 2.901 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)