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NDB ID: NA1975    PDB ID: 4GL2 


Title:

STRUCTURAL BASIS FOR DSRNA DUPLEX BACKBONE RECOGNITION BY MDA5

Molecular Description:

Interferon-induced helicase C domain-containing protein 1 (E.C.3.6.4.13)

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., Hur, S.
Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5. 
Cell(Cambridge,Mass.), 152, pp. 276 - 289, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 71.112   b = 154.748   c = 185.006 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.8_1069) program. The R value is 0.2782 for 24044 reflections in the resolution range 118.699 to 3.557 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)