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NDB ID: NA2100    PDB ID: 4GPW 


Title:

CRYSTAL STRUCTURE OF THE PROTOZOAL CYTOPLASMIC RIBOSOMAL DECODING SITE IN COMPLEX WITH 6'-HYDROXYSISOMICIN (P21212 FORM)

Molecular Description:

5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'
6'-hydroxysisomicin

Structural Keywords:

A DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kondo, J., Koganei, M., Maianti, J.P., Ly, V.L., Hanessian, S.
Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites 
Chemmedchem, 8, pp. 733 - 739, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 33.791   b = 92.293   c = 47.492 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.3 program. The R value is 0.0 for 3262 reflections in the resolution range 46.2 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)