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NDB ID: NA2158    PDB ID: 4IFD 


Title:

CRYSTAL STRUCTURE OF AN 11-SUBUNIT EUKARYOTIC EXOSOME COMPLEX BOUND TO RNA

Molecular Description:

Exosome complex component RRP45
Exosome complex component SKI6
Exosome complex component RRP43
Exosome complex component RRP46
Exosome complex component RRP42
Exosome complex component MTR3
Exosome complex component RRP40
Exosome complex component CSL4
Exosome complex exonuclease DIS3 (E.C.3.1.13.-
3.1.26.-)
Exosome complex exonuclease RRP6 (E.C.3.1.13.-)

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 11 protein sequences

Primary Citation:

Makino, D.L., Baumgartner, M., Conti, E.
Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex. 
Nature, 495, pp. 70 - 75, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 154.09   b = 107.44   c = 150.46 (Ångstroms)

α = 90.0   β = 110.63   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.8.1_1168) program. The R value is 0.1846 for 99101 reflections in the resolution range 49.638 to 2.805 Ångstroms with Fobs >  1.99 sigma(Fobs) and with I >  0.0 sigma(I)