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NDB ID: NA2180    PDB ID: 4IBV 


Title:

HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C AND SECOND-SITE SUPPRESSOR MUTATION S240R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA

Molecular Description:

Cellular tumor antigen p53

Deposited:

2012-12-09

Released:

2013-08-14

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Eldar, A., Rozenberg, H., Diskin-Posner, Y., Rohs, R., Shakked, Z.
Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. 
Nucleic Acids Res., 41, pp. 8748 - 8759, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 137.631   b = 50.302   c = 34.008 (Ångstroms)

α = 90.0   β = 93.46   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1648 for 13262 reflections in the resolution range 47.235 to 2.1 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)