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NDB ID: NA2186    PDB ID: 4IOC 


Title:

CRYSTAL STRUCTURE OF COMPOUND 4F BOUND TO LARGE RIBOSOMAL SUBUNIT (50S) FROM DEINOCOCCUS RADIODURANS

Molecular Description:

50S ribosomal subunit

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 28 protein sequences

Primary Citation:

Magee, T.V., Han, S., McCurdy, S.P., Nguyen, T.T., Granskog, K., Marr, E.S., Maguire, B.A., Huband, M.D., Chen, J.M., Subashi, T.A., Shanmugasundaram, V.
Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. 
Bioorg.Med.Chem.Lett., 23, pp. 1727 - 1731, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 169.64   b = 408.49   c = 692.91 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the autobuster program. The R value is 0.2003 for 242870 reflections in the resolution range 30.0 to 3.6 Ångstroms with Fobs >  1.0 sigma(Fobs) and with I >  0.0 sigma(I)