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NDB ID: NA2191    PDB ID: 4B3P 


Title:

STRUCTURES OF HIV-1 RT AND RNA-DNA COMPLEX REVEAL A UNIQUE RT CONFORMATION AND SUBSTRATE INTERFACE

Molecular Description:

REVERSE TRANSCRIPTASE/RIBONUCLEASE H (E.C.2.7.7.49
2.7.7.7
3.1.26.13
3.4.23.16
3.1.13.2)
P51 RT (E.C.2.7.7.49
2.7.7.7
3.1.26.13
3.4.23.16)

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Lapkouski, M., Tian, L., Miller, J.T., Le Grice, S.F.J., Yang, W.
Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation 
Nat.Struct.Mol.Biol., 20, pp. 230 - , 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61 2 2

Cell Constants:

a = 163.0   b = 163.0   c = 229.6 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX (PHENIX.REFINE) program. The R value is 0.3663 for 9023 reflections in the resolution range 46.096 to 4.839 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)