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NDB ID: NA2200    PDB ID: 4IQX 


Title:

MUTANT P44S P169S M296I OF FOOT-AND-MOUTH DISEASE VIRUS RNA-DEPENDENT RNA POLYMERASE

Molecular Description:

3D polymerase/DNA complex

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Agudo, R., Ferrer-Orta, C., Arias, A., de la Higuera, I., Perales, C., Perez-Luque, R., Verdaguer, N., Domingo, E.
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape. 
Plos Pathog., 6, pp. e1001072 - e1001072, 2010.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 93.836   b = 93.836   c = 99.867 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.2.0019 program. The R value is 0.22341 for 16981 reflections in the resolution range 29.36 to 2.5 Ångstroms with Fobs >  1.0 sigma(Fobs) and with I >  0.0 sigma(I)