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NDB ID: NA2237    PDB ID: 4GV6 


Title:

STRUCTURES OF LASSA AND TACARIBE VIRAL NUCLEOPROTEINS WITH OR WITHOUT 5 TRIPHOSPHATE DSRNA SUBSTRATE REVEAL A UNIQUE 3 -5 EXORIBONUCLEASE MECHANISM TO SUPPRESS TYPE I INTERFERON PRODUCTION

Molecular Description:

Nucleoprotein/RNA Complex

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. 
J.Biol.Chem., 288, pp. 16949 - 16959, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 46.51   b = 46.51   c = 208.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.6.0117 program. The R value is 0.19 for 16160 reflections in the resolution range 52.16 to 1.98 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)