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NDB ID: NA2319    PDB ID: 4J8V 


Title:

X-RAY STRUCTURE OF NCP145 WITH BOUND CHLORIDO(ETA-6-P-CYMENE)(N-PHENYL-2-PYRIDINECARBOTHIOAMIDE)RUTHENIUM(II)

Molecular Description:

Histone H3.2
Histone H4
Histone H2A
Histone H2B 1.1/DNA complex

Deposited:

2013-02-15

Released:

2013-05-08

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Meier, S.M., Hanif, M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M.A., Arion, V.B., Davey, C.A., Keppler, B.K., Hartinger, C.G.
Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
CHEM SCI, 4, pp. 1837 - 1846, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 106.8   b = 109.81   c = 182.38 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2525 for 55962 reflections in the resolution range 94.07 to 2.58 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)