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NDB ID: NA2344    PDB ID: 4K32 


Title:

CRYSTAL STRUCTURE OF GENETICIN BOUND TO THE LEISHMANIAL RRNA A-SITE

Molecular Description:

5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'

Structural Keywords:

B DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Shalev, M., Kondo, J., Kopelyanskiy, D., Jaffe, C.L., Adir, N., Baasov, T.
Identification of the molecular attributes required for aminoglycoside activity against Leishmania. 
Proc.Natl.Acad.Sci.USA, 110, pp. 13333 - 13338, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 33.08   b = 90.76   c = 47.01 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.6.1_357) program. The R value is 0.2096 for 4290 reflections in the resolution range 23.505 to 2.5 Ångstroms with Fobs >  2.04 sigma(Fobs) and with I >  0.0 sigma(I)