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NDB ID: NA2434    PDB ID: 4K4H 


Title:

TERNARY CRYSTAL STRUCTURES OF A HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.

Molecular Description:

DNA polymerase lambda (E.C.2.7.7.7
4.2.99.-)/DNA complex

Deposited:

2013-04-12

Released:

2014-07-16

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Vyas, R., Zahurancik, W.J., Suo, Z.
Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda. 
Proc.Natl.Acad.Sci.USA, 111, pp. E3033 - E3042, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 194.95   b = 97.44   c = 105.17 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.20698 for 106076 reflections in the resolution range 40.88 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)