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NDB ID: NA2606    PDB ID: 4B3S 


Title:

CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 37

Molecular Description:

30S RIBOSOMAL PROTEIN S2
30S RIBOSOMAL PROTEIN S3
30S RIBOSOMAL PROTEIN S4
30S RIBOSOMAL PROTEIN S5
30S RIBOSOMAL PROTEIN S6
30S RIBOSOMAL PROTEIN S7
30S RIBOSOMAL PROTEIN S8
30S RIBOSOMAL PROTEIN S9
30S RIBOSOMAL PROTEIN S10
30S RIBOSOMAL PROTEIN S11
30S RIBOSOMAL PROTEIN S12
30S RIBOSOMAL PROTEIN S13
30S RIBOSOMAL PROTEIN S14 TYPE Z
30S RIBOSOMAL PROTEIN S15
30S RIBOSOMAL PROTEIN S16
30S RIBOSOMAL PROTEIN S17
30S RIBOSOMAL PROTEIN S18
30S RIBOSOMAL PROTEIN S19
30S RIBOSOMAL PROTEIN S20
30S RIBOSOMAL PROTEIN THX/RNA Complex
(1R
2R
3S
4R
6S)-4
6-DIAMINO-2-{[3-O-(2
6-DIAMINO-2
6-DIDEOXY-BETA-L-IDOPYRANOSYL)-BETA-D-RIBOFURANOSYL]OXY}-3-HYDROXYCYCLOHEXYL 2-AMINO-4-O-BENZYL-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 20 protein sequences

Primary Citation:

Perez-Fernandez, D., Shcherbakov, D., Matt, T., Leong, N.C., Kudyba, I., Duscha, S., Boukari, H., Patak, R., Dubakka, S.R., Lang, K., Meyer, M., Akbergenov, R., Freihofer, P., Vaddi, S., Thommes, P., Ramakrishnan, V., Vasella, A., Bottger, E.C.
4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics 
Nat.Commun., 5, pp. 3112 - , 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 401.15   b = 401.15   c = 173.64 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.2 program. The R value is 0.2104 for 240081 reflections in the resolution range 40.0 to 3.15 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)