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NDB ID: NA2612    PDB ID: 4LZ4 


Title:

X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN THROMBIN AND THE TBA DELETION MUTANT LACKING THYMINE 3 NUCLEOBASE

Molecular Description:

Thrombin light chain (E.C.3.4.21.5)
Thrombin heavy chain (E.C.3.4.21.5)

Deposited:

2013-07-31

Released:

2014-01-08

Structural Keywords:

QUADRUPLE HELIX, FLIPPED-OUT BASE

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Pica, A., Russo Krauss, I., Merlino, A., Nagatoishi, S., Sugimoto, N., Sica, F.
Dissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamer. 
Febs J., 280, pp. 6581 - 6588, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 61.736   b = 120.725   c = 67.233 (Ångstroms)

α = 90.0   β = 94.22   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CCP4 program. The R value is 0.17114 for 27048 reflections in the resolution range 29.62 to 2.56 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)