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NDB ID: NA2679    PDB ID: 4M8O 


Title:

TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING DATP

Molecular Description:

DNA polymerase epsilon catalytic subunit A (E.C.2.7.7.7)

Deposited:

2013-08-13

Released:

2013-11-27

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hogg, M., Osterman, P., Bylund, G.O., Ganai, R.A., Lundstrom, E.B., Sauer-Eriksson, A.E., Johansson, E.
Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon. 
Nat.Struct.Mol.Biol., 21, pp. 49 - 55, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 148.495   b = 68.919   c = 149.852 (Ångstroms)

α = 90.0   β = 109.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.183 for 69054 reflections in the resolution range 47.05 to 2.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)