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NDB ID: NA2742    PDB ID: 4MZR 


Title:

CRYSTAL STRUCTURE OF A POLYPEPTIDE P53 MUTANT BOUND TO DNA

Molecular Description:

Cellular tumor antigen p53

Deposited:

2013-09-30

Released:

2014-01-15

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Emamzadah, S., Tropia, L., Vincenti, I., Falquet, B., Halazonetis, T.D.
Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein. 
J.Mol.Biol., 426, pp. 936 - 944, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 163.298   b = 169.764   c = 55.664 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.234 for 4796 reflections in the resolution range 80.0 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)