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NDB ID: NA2750    PDB ID: 4NI7 


Title:

CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN 6 IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL1025)

Molecular Description:

Interleukin-6

Deposited:

2013-11-05

Released:

2014-01-22

Structural Keywords:

, BASE TETRAPLEX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Gelinas, A.D., Davies, D.R., Edwards, T.E., Rohloff, J.C., Carter, J.D., Zhang, C., Gupta, S., Ishikawa, Y., Hirota, M., Nakaishi, Y., Jarvis, T.C., Janjic, N.
Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand. 
J.Biol.Chem., 289, pp. 8720 - 8734, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32

Cell Constants:

a = 50.23   b = 50.23   c = 103.63 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.224 for 11384 reflections in the resolution range 43.5 to 2.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)