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NDB ID: NA2799    PDB ID: 4NQA 


Title:

CRYSTAL STRUCTURE OF LIGANDED HRXR-ALPHA/HLXR-BETA HETERODIMER ON DNA

Molecular Description:

Retinoic acid receptor RXR-alpha
Liver X nuclear receptor beta
Nuclear receptor coactivator 2

Deposited:

2013-11-24

Released:

2014-02-26

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Lou, X., Toresson, G., Benod, C., Suh, J.H., Philips, K.J., Webb, P., Gustafsson, J.A.
Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA. 
Nat.Struct.Mol.Biol., 21, pp. 277 - 281, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43

Cell Constants:

a = 85.783   b = 85.783   c = 238.577 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1864 for 25687 reflections in the resolution range 48.971 to 3.102 Ångstroms with Fobs >  1.38 sigma(Fobs) and with I >  0.0 sigma(I)