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NDB ID: NA2825    PDB ID: 4NY8 


Title:

DNA POLYMERASE BETA WITH O6MG IN THE TEMPLATE BASE OPPOSITE TO INCOMING NON-HYDROLYZABLE CTP WITH MANGANESE IN THE ACTIVE SITE

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)

Deposited:

2013-12-10

Released:

2014-04-16

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Koag, M.C., Lee, S.
Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. 
J.Am.Chem.Soc., 136, pp. 5709 - 5721, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.625   b = 79.288   c = 54.838 (Ångstroms)

α = 90.0   β = 105.97   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2091 for 20960 reflections in the resolution range 19.822 to 2.246 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)