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NDB ID: NA2832    PDB ID: 4O41 


Title:

AMIDE LINKED RNA

Molecular Description:

5'-R(*UP*GP*AP*GP*CP*(URU)P*CP*GP*GP*CP*UP*CP*(W)P*(H)P*(E)P*(R)P*(E)P*UP*(R)P*UP*IP*(S)P*TP*(H)P*(E)P*AP*(M)P*IP*(D)P*(E)P*(L)P*IP*(N)P*(K)P*(E)P*(D)P*(R)P*(E)P*(S)P*IP*(D)P*UP*(E))-3'

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Mutisya, D., Selvam, C., Lunstad, B.D., Pallan, P.S., Haas, A., Leake, D., Egli, M., Rozners, E.
Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs. 
Nucleic Acids Res., 42, pp. 6542 - 6551, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 22.36   b = 34.33   c = 43.3 (Ångstroms)

α = 110.03   β = 94.24   γ = 95.83 (degrees)

Refinement:

The structure was refined using the SHELXL-97 program. The R value is 0.0 for 35886 reflections in the resolution range 28.0 to 1.2 Ångstroms with Fobs >  3.0 sigma(Fobs) and with I >  0.0 sigma(I)