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NDB ID: NA2975    PDB ID: 4Q0B 


Title:

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GAP-RNA/DNA AND NEVIRAPINE

Molecular Description:

HIV-1 reverse transcriptase
p66 subunit (E.C.2.7.7.49
2.7.7.7
3.1.26.13
3.1.13.2)
HIV-1 reverse transcriptase
p51 subunit (E.C.2.7.7.49
2.7.7.7)

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.E., Bandwar, R.P., Arnold, E.
Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. 
Nucleic Acids Res., 42, pp. 8125 - 8137, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.716   b = 131.051   c = 141.631 (Ångstroms)

α = 90.0   β = 100.69   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (phenix.refine: 1.8.4_1496) program. The R value is 0.2373 for 47852 reflections in the resolution range 46.391 to 3.3 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)