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NDB ID: NA2994    PDB ID: 4QCL 


Title:

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN RNA-PRIMED DNA TEMPLATE AND DCTP

Molecular Description:

DNA polymerase alpha catalytic subunit (E.C.2.7.7.7)

Deposited:

2014-05-12

Released:

2014-11-26

Structural Keywords:

RH DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Baranovskiy, A.G., Duong, V., Babayeva, N.D., Zhang, Y., Pavlov, Y., Anderson, K., Tahirov, T.H.
Activity and fidelity of human DNA polymerase alpha depend on primer structure
J.Biol.Chem., , pp. - , 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 140.763   b = 140.763   c = 181.315 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.21 for 93409 reflections in the resolution range 29.51 to 2.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)