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NDB ID: NA3000    PDB ID: 3WTU 


Title:

CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1 (V170A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA

Molecular Description:

Runt-related transcription factor 1
Core-binding factor subunit beta
Protein C-ets-1/DNA

Deposited:

2014-04-21

Released:

2014-08-13

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Shiina, M., Hamada, K., Inoue-Bungo, T., Shimamura, M., Uchiyama, A., Baba, S., Sato, K., Yamamoto, M., Ogata, K.
A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions 
J.Mol.Biol., , pp. - , 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 78.558   b = 102.11   c = 194.945 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.232 for 43409 reflections in the resolution range 48.74 to 2.7 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)