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NDB ID: NA3156    PDB ID: 4R5P 


Title:

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) WITH DNA AND A NUCLEOSIDE TRIPHOSPHATE MIMIC ALPHA-CARBOXY NUCLEOSIDE PHOSPHONATE INHIBITOR

Molecular Description:

HIV-1 reverse transcriptase
p66 subunit (E.C.2.7.7.49
2.7.7.7
3.1.26.13
3.1.13.2)
HIV-1 reverse transcriptase
p51 subunit (E.C.2.7.7.49
2.7.7.7)

Deposited:

2014-08-21

Released:

2015-03-11

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Balzarini, J., Das, K., Bernatchez, J.A., Martinez, S.E., Ngure, M., Keane, S., Ford, A., Maguire, N., Mullins, N., John, J., Kim, Y., Dehaen, W., Vande Voorde, J., Liekens, S., Naesens, L., Gotte, M., Maguire, A.R., Arnold, E.
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. 
Proc.Natl.Acad.Sci.USA, 112, pp. 3475 - 3480, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.905   b = 133.529   c = 139.218 (Ångstroms)

α = 90.0   β = 97.81   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1965 for 72084 reflections in the resolution range 44.536 to 2.894 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)