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NDB ID: NA3212    PDB ID: 4RIB 


Title:

FAN1 NUCLEASE BOUND TO 5' PHOSPHORYLATED P(DT) SINGLE FLAP DNA

Molecular Description:

Fanconi-associated nuclease 1 (E.C.3.1.21.-
3.1.4.1)/dna

Deposited:

2014-10-05

Released:

2014-12-03

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, R., Persky, N.S., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S.J., Pavletich, N.P.
DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. 
Science, 346, pp. 1127 - 1130, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 97.697   b = 110.989   c = 105.427 (Ångstroms)

α = 90.0   β = 103.75   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.22744 for 31391 reflections in the resolution range 50.0 to 3.25 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)