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NDB ID: NA3313    PDB ID: 4RUA 


Title:

CRYSTAL STRUCTURE OF Y-FAMILY DNA POLYMERASE DPO4 BYPASSING A MEFAPY-DG ADDUCT

Molecular Description:

DNA polymerase IV (EC:2.7.7.7)/DNA complex

Deposited:

2014-11-18

Released:

2015-08-05

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Patra, A., Banerjee, S., Johnson Salyard, T.L., Malik, C.K., Christov, P.P., Rizzo, C.J., Stone, M.P., Egli, M.
Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. 
J.Am.Chem.Soc., 137, pp. 7011 - 7014, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 95.451   b = 102.716   c = 53.432 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.16843 for 9612 reflections in the resolution range 50.0 to 3.07 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)