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NDB ID: NA3322    PDB ID: 4RWN 


Title:

CRYSTAL STRUCTURE OF THE PRE-REACTIVE STATE OF PORCINE OAS1

Molecular Description:

2'-5'-oligoadenylate synthase 1 (E.C.2.7.7.84)/RNA

Deposited:

2014-12-05

Released:

2015-05-20

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Lohofener, J., Steinke, N., Kay-Fedorov, P., Baruch, P., Nikulin, A., Tishchenko, S., Manstein, D.J., Fedorov, R.
The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. 
Structure, 23, pp. 851 - 862, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 72.4   b = 72.4   c = 205.95 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.19 for 37859 reflections in the resolution range 41.04 to 2.0 Ångstroms with Fobs >  1.42 sigma(Fobs) and with I >  0.0 sigma(I)