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NDB ID: PD0020    PDB ID: 1BC8 


Title:

STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS

Molecular Description:

SAP-1 ETS DOMAIN/DNA COMPLEX

Deposited:

1998-05-05

Released:

1998-12-01

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Mo, Y., Vaessen, B., Johnston, K., Marmorstein, R.
Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. 
Mol.Cell, 2, pp. 201 - 212, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 31.59   b = 55.67   c = 44.23 (Ångstroms)

α = 90.0   β = 107.16   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.22 for 10700 reflections in the resolution range 28.9 to 1.93 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)