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NDB ID: PD0034    PDB ID: 10MH 


Title:

TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET

Molecular Description:

CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX

Deposited:

1998-08-10

Released:

1999-02-09

Structural Keywords:

B DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Jr., H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'gara, M., Cheng, X.
Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. 
J.Mol.Biol., 285, pp. 2021 - 2034, 1999.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3 2

Cell Constants:

a = 99.86   b = 99.86   c = 325.2 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.205 for 15965 reflections in the resolution range 29.3 to 2.55 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)