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NDB ID: PD0053    PDB ID: 2SSP 


Title:

LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA

Molecular Description:

URACIL-DNA GLYCOSYLASE/DNA COMPLEX

Deposited:

1999-04-28

Released:

1999-05-06

Structural Keywords:

RH DOUBLE HELIX, FLIPPED-OUT BASE, OVERHANGING BASE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Parikh, S.S., Mol, C.D., Slupphaug, G., Bharati, S., Krokan, H.E., Tainer, J.A.
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA. 
EMBO J., 17, pp. 5214 - 5226, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 120.3   b = 48.8   c = 65.6 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.184 for 17195 reflections in the resolution range 20.0 to 2.25 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)