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NDB ID: PD0093    PDB ID: 1DE8 


Title:

HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1) BOUND TO ABASIC DNA

Molecular Description:

MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE (E.C.4.2.99.18)/DNA COMPLEX

Deposited:

1999-11-13

Released:

2000-02-02

Structural Keywords:

B DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A.
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected 
Nature, 403, pp. 451 - 456, 2000.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 41

Cell Constants:

a = 122.85   b = 122.85   c = 107.07 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.19 for 11215 reflections in the resolution range 20.0 to 2.95 Ångstroms with Fobs >  3.0 sigma(Fobs) and with I >  0.0 sigma(I)