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NDB ID: PD0117    PDB ID: 1EBM 


Title:

CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE

Molecular Description:

8-OXOGUANINE DNA GLYCOSYLASE/DNA COMPLEX

Deposited:

2000-01-24

Released:

2000-03-20

Structural Keywords:

B DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Bruner, S.D., Norman, D.P., Verdine, G.L.
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. 
Nature, 403, pp. 859 - 866, 2000.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 92.357   b = 92.357   c = 212.872 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.235 for 29194 reflections in the resolution range 25.0 to 2.1 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  1.0 sigma(I)