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NDB ID: PD0125    PDB ID: 1EJ9 


Title:

CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX

Molecular Description:

Deposited:

2000-03-01

Released:

2000-08-03

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Redinbo, M.R., Champoux, J.J., Hol, W.G.
Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. 
Biochemistry, 39, pp. 6832 - 6840, 2000.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 56.98   b = 124.92   c = 72.29 (Ångstroms)

α = 90.0   β = 93.84   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.0 for 29616 reflections in the resolution range 15.0 to 2.6 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  1.0 sigma(I)