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NDB ID: PD0255    PDB ID: 1K4S 


Title:

HUMAN DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Molecular Description:

DNA TOPOISOMERASE I (E.C.5.99.1.2)/DNA Complex

Deposited:

2001-10-08

Released:

2002-12-04

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin Jr., A.B., Stewart, L.J.
The mechanism of topoisomerase I poisoning by a camptothecin analog 
Proc.Natl.Acad.Sci.USA, 99, pp. 15387 - 15392, 2002.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32

Cell Constants:

a = 73.235   b = 73.235   c = 186.632 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNX program. The R value is 0.0 for 17874 reflections in the resolution range 50.0 to 3.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)