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NDB ID: PD0313    PDB ID: 1LPQ 


Title:

HUMAN DNA TOPOISOMERASE I (70 KDA) IN NON-COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX CONTAINING AN 8-OXOG LESION

Molecular Description:

DNA topoisomerase I (E.C.5.99.1.2)/DNA Complex

Deposited:

2002-05-08

Released:

2002-08-16

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Lesher, D.T., Pommier, Y., Stewart, L., Redinbo, M.R.
8-Oxoguanine rearranges the active site of human topoisomerase I 
Proc.Natl.Acad.Sci.USA, 99, pp. 12102 - 12107, 2002.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 57.2   b = 122.5   c = 72.0 (Ångstroms)

α = 90.0   β = 97.4   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 16401 reflections in the resolution range 19.87 to 3.14 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)